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Senna is also the primary ingredient found in most "dieter's teas". The combination of acting as a stimulant which reduces a dieter's appetite, and the laxative properties that cause food to move through their system before as many calories can be absorbed is a combination that can lead to rapid and even dangerous weight loss. The stimulant action of sennosides should be taken into account for those who suffer from any conditions where stimulants are contraindicated, such as past heart disease, high blood pressure, anxiety attacks, etc. A (generally invisible and harmless) side effect of taking Senna medication regularly is Melanosis coli, a brown discoloration of the colon wall.

The long-standing use of (mainly) Alexandrian Senna is reflected by its presence in many herbal remedies and tonics. These include for example Black draught, Catholicon, Daffy's Elixir, Diasenna (literally meaning "composed of senna") and Swedish bitters. On the other hand, it was contained in more dangerous "medications" such as the highly toxic antihelminthic Lumbricide and - because their purgative effects are a readily-observed "proof" that some concoction "works" - many generally useless and often poisonous "patent medicine".

Cassia gum - a commonly-used thickening agent -, despite its name is actually from Chinese Senna (S. obtusifolia) seeds. In some Southeast Asian cuisines (particularly those of Thailand and Laos), the leaves and flowers of Siamese Senna (S. siamea, called khi-lek in Thai), either fresh or pickled in brine, are used in cooking, particularly in gaeng khi-lek (khi-lek curry)

 
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